PENGARUH PEMBERIAN EKSTRAK DAUN BELIMBING WULUH (Averrhoa blimbi L.) DAN DAUN JARAK PAGAR (Jatropha curcas L.) TERHADAP KADAR GLUKOSA MENCIT (Mus musculus L.)

Bahasa Indonesia

Abstract

This study aimed to determine the effect of giving starfruit leaf extract and Jatropha leaf extract, a mixture
of starfruit leaf extract and Jatropha leaf extract and glucobay drug (Acarbose) on glucose levels of mice. A total
of 20 mice weighing 20-30 grams aged 2-3 months were divided into 5 treatment groups namely K0 as a 5%
glucose control, K1 (5% glucose solution and glucobay drug), K2 (5% glucose solution and leaf extract starfruit
wuluh), K3 (5% glucose solution and Jatropha leaf extract) and K4 (5% glucose solution, a mixture of starfruit leaf
extract and Jatropha leaves). Mice were first measured initial glucose levels. Giving 5% glucose solution, carried
out for 14 days so as to reach the condition of hyperglycemia. Treated with starfruit leaf extract, jatropha leaf extract
and a mixture of starfruit leaf extract and jatropha leaves with the same dose that is 400 mg / gr BW, administering
synthetic drug glucobay with a dose of 6.5 mg / gr BB for 14 days and calculated final glucose level. The results
showed that the administration of starfruit leaf extract and Jatropha leaf extract, the mixture of Wuluh starfruit leaf
extract and Jatropha leaf extract and glucobay drug influenced the treatment group. Based on the analysis using
the LSD test (α = 0.05) significantly different in the F test (ANOVA). In the LSD test in the treatment (K1, K2, K3 and
K4) decreased compared to K0 as glucose control. The highest reduction in glucose levels was found in the K3
treatment (70 mg / dL).